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Transgene Detail
Symbol: Tg(ACTB-THRB*)#Syc
Name: transgene insertion, Sheue-yann Cheng
MGI ID: MGI:5529516
Transgene: Tg(ACTB-THRB*)#Syc  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(ACTB-THRB*)#Syc expresses 1 gene
Mutation detailsThis transgene consists of the human beta-actin promoter driving the expression of a human thyroid hormone beta1 receptor cDNA isolated from the PV kindred with Generalized Resistance to Thyroid Hormone containing a C-insertion at nucleotide 1627 (codon 443). This insertion results in a frame shift of the carboxy terminal 16 amino acids resulting in a total loss of T3-binding and transcriptional activation behaving as a dominant negative. Three founder lines were established: A,D, and G. RT-PCR and immunohistochemistry confirmed expression of RNA and protein. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:134187)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:134187 Wong R, et al., Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity. Mol Med. 1997 May;3(5):303-14
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory