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Tg(Sirt1)ASrn
Transgene Detail
Nomenclature
Symbol: Tg(Sirt1)ASrn
Name: transgene insertion A, Manuel Serrano
MGI ID: MGI:5529482
Synonyms: SIRT1super, Sirt1-tg
Transgene: Tg(Sirt1)ASrn  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Sirt1)ASrn expresses 1 gene
 
Mutation detailsBacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 174 kb BAC (#RP23-119G23) containing the entire mouse Sirt1 gene and the adjacent Dnajc12 gene. Overexpression of Dnajc12 is not expected to affect Sirt1 molecular pathways. The one founder mouse created exhibits a 2-4 fold overexpression of SIRT1 protein in liver, kidney, thymus, spleen, colon and jejunum/ileum. (J:137868)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:137868 Pfluger PT, et al., Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9793-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory