Tg(Sirt1)ASrn
Transgene Detail

Summary

• Symbol: Tg(Sirt1)ASrn
• Name: transgene insertion A, Manuel Serrano
• MGI ID: MGI:5529482
• Synonyms: SIRT1^super, Sirt1-tg
• Transgene: Tg(Sirt1)ASrn Location: unknown
• Alliance: Tg(Sirt1)ASrn page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Sirt1)ASrn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sirt1 (MGI:2135607)

• Mutation details: Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 174 kb BAC (#RP23-119G23) containing the entire mouse Sirt1 gene and the adjacent Dnajc12 gene. Overexpression of Dnajc12 is not expected to affect Sirt1 molecular pathways. The one founder mouse created exhibits a 2-4 fold overexpression of SIRT1 protein in liver, kidney, thymus, spleen, colon and jejunum/ileum. (J:137868)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:137868 Pfluger PT, et al., Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9793-8
• All: 10 reference(s)