Fermt1^tm2Ref
Targeted Allele Detail

Summary

• Symbol: Fermt1^tm2Ref
• Name: fermitin family member 1; targeted mutation 2, Reinhard Fassler
• MGI ID: MGI:5529147
• Synonyms: Fermt-1^flox
• Gene: Fermt1 Location: Chr2:132746309-132787826 bp, - strand Genetic Position: Chr2, 64.8 cM
• Alliance: Fermt1^tm2Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185558
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:185558, J:210448)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fermt1 Mutation: 31 strains or lines available

References

• Original: J:185558 Bottcher RT, et al., Sorting nexin 17 prevents lysosomal degradation of beta1 integrins by binding to the beta1-integrin tail. Nat Cell Biol. 2012 Jun;14(6):584-92
• All: 3 reference(s)