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Targeted Allele Detail
Symbol: Acot7tm1.1Mwol
Name: acyl-CoA thioesterase 7; targeted mutation 1.1, Michael J Wolfgang
MGI ID: MGI:5528815
Synonyms: Acot7flox
Gene: Acot7  Location: Chr4:152178134-152271855 bp, + strand  Genetic Position: Chr4, 82.93 cM
Germline Transmission:  Earliest citation of germline transmission: J:203753
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted usptream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:203753)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acot7 Mutation:  24 strains or lines available
Original:  J:203753 Ellis JM, et al., Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity. Mol Cell Biol. 2013 May;33(9):1869-82
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory