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Targeted Allele Detail
Symbol: Chst14tm1.1Msch
Name: carbohydrate sulfotransferase 14; targeted mutation 1.1, Melitta Schachner
MGI ID: MGI:5528395
Gene: Chst14  Location: Chr2:118926497-118928585 bp, + strand  Genetic Position: Chr2, 59.73 cM, cytoband E5
Germline Transmission:  Earliest citation of germline transmission: J:203583
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of the coding exon. An FRT- and loxP-flanked neomycin resistance cassette with a dsRED gene was inserted downstream of the coding exon. Cre-mediated recombination removed the coding exon and neomycin resistance cassette. RT-PCR and northern blot analysis confirmed the absence of transcript expression. (J:203583)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chst14 Mutation:  11 strains or lines available
Original:  J:203583 Akyuz N, et al., Dermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration. Exp Neurol. 2013 Sep;247:517-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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