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Tg(MMTV-ERBB2)5Erick
Transgene Detail
Summary
Symbol: Tg(MMTV-ERBB2)5Erick
Name: transgene insertion 5, Sharon Erickson
MGI ID: MGI:5527316
Synonyms: Fo5, MMTV.f.huHER2 #5, MMTV-HER2
Transgene: Tg(MMTV-ERBB2)5Erick  Location: unknown  Genetic Position: Chr6, Syntenic
Alliance: Tg(MMTV-ERBB2)5Erick page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MMTV-ERBB2)5Erick expresses 1 gene
 
Mutation detailsThis transgene contains the MMTV promoter, the 3' of human growth hormone exons 4 and 5, and the human ERBB2 cDNA with the ATG removed. The transgene integrated at a single site on chromosome 6 and quantitative PCR analysis suggests a transgene copy number of 30-50. (J:90202)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(MMTV-ERBB2)5Erick
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:90202 Finkle D, et al., HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice. Clin Cancer Res. 2004 Apr 1;10(7):2499-511
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory