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Spontaneous Allele Detail
Symbol: Cyfip2M1N
Name: cytoplasmic FMR1 interacting protein 2; mutation 1, National Institutes of Health
MGI ID: MGI:5527294
Synonyms: Cyfip2B6N
Gene: Cyfip2  Location: Chr11:46193850-46312859 bp, - strand  Genetic Position: Chr11, 27.61 cM, cytoband B1.2
Strain of Origin:  C57BL/6N
Allele Type:    Spontaneous
Mutation:    Single point mutation
Mutation detailsAn G to A mutation at 46,036,117 base pair (bp) of chromosome 11 (mm9) occured between 1961 and 1974 in the C57BL/6N strain that resulted in the amino acid substitution of phenylalanine for serine at position 968 (S968F). This mutation is found in all C57BL/6N substrains (C57BL/6NCrl, C57BL/6NTac and C57BL/6NJ) but is not present in the C57BL/6J strain or substrains (C57BL/6Ei, C57BL/6EiJ, C57BL/6ByJ and C57BL/6By). The mutation destabilizes the protein leading to decreased half-life. (J:203183)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyfip2 Mutation:  7 strains or lines available
Original:  J:203183 Kumar V, et al., C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science. 2013 Dec 20;342(6165):1508-12
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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