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Tectatm4.1Gpr
Targeted Allele Detail
Nomenclature
Symbol: Tectatm4.1Gpr
Name: tectorin alpha; targeted mutation 4.1, Guy P Richardson
MGI ID: MGI:5527095
Synonyms: TectaL1820F, G1824D
Gene: Tecta  Location: Chr9:42329619-42399929 bp, - strand  Genetic Position: Chr9, 23.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203482
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsNucleotide substitutions (c.5458C>T, c.5471G>A in NM_009347) result in the amino acid substitutions of lysine with phenylalanine at position 1820 (p.L1820F) and glycine with aspartic acid at position 1824 (p.G1824D). Cre-mediated recombination removed the loxP site flanked neomycin resistance gene cassette that was also inserted. (J:203482)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tecta Mutation:  86 strains or lines available
References
Original:  J:203482 Legan PK, et al., Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane. Hum Mol Genet. 2014 May 15;23(10):2551-68
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory