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Bcrtm1(BCR/ABL)Tsr
Targeted Allele Detail
Nomenclature
Symbol: Bcrtm1(BCR/ABL)Tsr
Name: BCR activator of RhoGEF and GTPase; targeted mutation 1, Theodora S Ross
MGI ID: MGI:5524984
Synonyms: BcrLSL-B/A, BcrLSL-BCR/ABL
Gene: Bcr  Location: Chr10:75060592-75184921 bp, + strand  Genetic Position: Chr10, 38.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203111
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsHuman BCR/ABL p210-IRES-EGFP cDNA and an Frt-flanked neomycin cassette were introduced to exon 1 of the mouse Bcr gene downstream of a loxP-flanked Stop cassette via homologous recombination. (J:203111)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcr Mutation:  5 strains or lines available
References
Original:  J:203111 Foley SB, et al., Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia. Cell Rep. 2013 Oct 17;5(1):51-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory