Trp53^tm1.1Tldo
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Tldo
• Name: transformation related protein 53; targeted mutation 1.1, Franck Toledo
• MGI ID: MGI:5523909
• Synonyms: p53^delta31
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Tldo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199308
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Mice carrying a conditional Trp53 allele with a nonsense mutation in exon 10 were crossed to Tg(Pgk1-cre)1Lni mice to excise the floxed stop cassette. The resultant allele produces a Trp53 mRNA encoding a protein lacking the last 31 amino acids (the C terminal domain; CTD). (J:199308)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:199308 Simeonova I, et al., Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes. Cell Rep. 2013 Jun 27;3(6):2046-58
• All: 2 reference(s)