Trp53^tm1Tldo
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Tldo
• Name: transformation related protein 53; targeted mutation 1, Franck Toledo
• MGI ID: MGI:5523907
• Synonyms: p53^LSL-delta31
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Tldo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199308
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A targeting vector was generated with a nonsense mutation in exon 10 that would delete the final 31 amino acids of the Trp53 gene. Upstream of the coding sequence was a transcriptional stop sequence and neo resistance marker flanked by loxP sites. The linearized targeting construct was electroporated into ES cells for homologous recombination. Chimeras were produced from injected blastocysts and germline transmission was verified. (J:199308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 249 strains or lines available

References

• Original: J:199308 Simeonova I, et al., Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes. Cell Rep. 2013 Jun 27;3(6):2046-58
• All: 1 reference(s)