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Flt1tm1.1Fong
Targeted Allele Detail
Nomenclature
Symbol: Flt1tm1.1Fong
Name: FMS-like tyrosine kinase 1; targeted mutation 1.1, Guo-Hua Fong
MGI ID: MGI:5523702
Synonyms: Vegfr-1flox
Gene: Flt1  Location: Chr5:147498414-147662821 bp, - strand  Genetic Position: Chr5, 87.01 cM, cytoband G
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:202202
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette and left exon 3 floxed. (J:202202)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Flt1 Mutation:  46 strains or lines available
References
Original:  J:202202 Ho VC, et al., Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice. Circulation. 2012 Aug 7;126(6):741-52
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory