Tg(Camk2a-HBEGF)ANkza
Transgene Detail

Summary

• Symbol: Tg(Camk2a-HBEGF)ANkza
• Name: transgene insertion A, Kazu Nakazawa
• MGI ID: MGI:5523549
• Synonyms: fDTR-line-A
• Transgene: Tg(Camk2a-HBEGF)ANkza Location: unknown
• Alliance: Tg(Camk2a-HBEGF)ANkza page

Transgene origin

• Strain of Origin: C57BL/6NTac

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-HBEGF)ANkza expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The fDTR transgene was designed with a loxP-flanked alkaline phosphatase-polyadenylation signal upstream of a human diphtheria toxin receptor (DTR; heparin-binding epidermal growth factor-like growth factor (HBEGF)) under the transcriptional control of the murine calcium/calmodulin-dependent protein kinase II alpha (CamKIIalpha) promoter. Lines A and B were generated with line B exhibiting reduced expression compared with line A. (J:197654)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:197654 Jinde S, et al., Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation. Neuron. 2012 Dec 20;76(6):1189-200
• All: 1 reference(s)