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Transgene Detail
Symbol: Tg(Camk2a-HBEGF)BNKza
Name: transgene insertion B, Kazu Nakazawa
MGI ID: MGI:5523547
Synonyms: DTRloxP, fDTR, fDTR-line-B
Transgene: Tg(Camk2a-HBEGF)BNKza  Location: unknown  
Strain of Origin:  C57BL/6N
Transgene Type:    Transgenic (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
Tg(Camk2a-HBEGF)BNKza expresses 1 gene
Mutation detailsA targeting construct contained the Camk2a promoter, a loxp flanked alkaline phosphates-pA stop cassette and the sequence for the human homolog of heparin-binding epidermal growth factor-like growth factor (HBEGF) which functions as a diphtheria toxin receptor (DTR) in mice. Lines A and B were generated with line B exhibiting reduced expression compared with line A. Upon cre-mediated excision of the floxed AP stop cassette, the DTR is expressed making it possible to ablate specific cell populations. (J:197654)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:197654 Jinde S, et al., Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation. Neuron. 2012 Dec 20;76(6):1189-200
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory