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Gnl3tm2.1Rylt
Targeted Allele Detail
Nomenclature
Symbol: Gnl3tm2.1Rylt
Name: guanine nucleotide binding protein-like 3 (nucleolar); targeted mutation 2.1, Robert Y L Tsai
MGI ID: MGI:5523416
Synonyms: NSf
Gene: Gnl3  Location: Chr14:31012433-31019131 bp, - strand  Genetic Position: Chr14, 19.09 cM
Severe brain defects in Gnl3tm2.1Rylt/Gnl3tm2.1Rylt Tg(Nes-cre)1Kln/0 embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198698
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site and FRT flanked pgk-neo cassette were inserted 820 bp upstream of exon 1 and a second loxP site was inserted in the second intron. Flp mediated recombination removed the neo cassette. (J:198698)
Generation of the Gnl3tm2.1Rylt and Gnl3tm2.2Rylt alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnl3 Mutation:  35 strains or lines available
References
Original:  J:198698 Meng L, et al., Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11415-20
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory