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Gata1tm2.1Yen
Targeted Allele Detail
Summary
Symbol: Gata1tm2.1Yen
Name: GATA binding protein 1; targeted mutation 2.1, Hsin-Fang Yang-Yen
MGI ID: MGI:5521598
Synonyms: GATA-1S26A
Gene: Gata1  Location: ChrX:7825504-7842844 bp, - strand  Genetic Position: ChrX, 3.59 cM, cytoband A2
Alliance: Gata1tm2.1Yen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200716
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 2 was replaced with a modified exon 2 in which nucleotide substitutions (TCA to GCC) results in the amino acid susbtitution of alanine for serine at position 26 (S26A). This mutation prevents phosphorylation at this site. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon 2. (J:200716)
Generation of the Gata1tm1.1Yen or Gata1tm2.1Yen alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata1 Mutation:  44 strains or lines available
References
Original:  J:200716 Lin KR, et al., Constitutive phosphorylation of GATA-1 at serine(2)(6) attenuates the colony-forming activity of erythrocyte-committed progenitors. PLoS One. 2013;8(5):e64269
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory