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Prkcitm1.1Rfar
Targeted Allele Detail
Nomenclature
Symbol: Prkcitm1.1Rfar
Name: protein kinase C, iota; targeted mutation 1.1, Robert V Farese Sr
MGI ID: MGI:5520927
Synonyms: PKCiota/lambda delta
Gene: Prkci  Location: Chr3:30995742-31052740 bp, + strand  Genetic Position: Chr3, 14.65 cM
Abnormal development of Prkcitm1.1Rfar/Prkcitm1.1Rfar embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:202124
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exon containing nucleotides 110-233 (exon 2) was flanked by loxP sites. A neomycin resistance cassette was inserted downstream of the exon. Cre-mediated recombination removed exon 2 and the neomycin resistance cassette. (J:202124)
Generation of the Prkcitm1.1Rfar allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkci Mutation:  54 strains or lines available
References
Original:  J:202124 Seidl S, et al., Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS One. 2013;8(5):e62756
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory