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Lin28btm1.2Gqda
Targeted Allele Detail
Nomenclature
Symbol: Lin28btm1.2Gqda
Name: lin-28 homolog B (C. elegans); targeted mutation 1.2, George Q Daley
MGI ID: MGI:5519954
Gene: Lin28b  Location: Chr10:45376617-45486314 bp, - strand  Genetic Position: Chr10, 23.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199720
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 2. FLP-mediated recombination removed the neomycin cassette. (J:101977, J:199720)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lin28b Mutation:  16 strains or lines available
References
Original:  J:199720 Shinoda G, et al., Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013 Aug;31(8):1563-73
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory