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Edn2tm1Ywa
Targeted Allele Detail
Nomenclature
Symbol: Edn2tm1Ywa
Name: endothelin 2; targeted mutation 1, Masashi Yanagisawa
MGI ID: MGI:5519239
Gene: Edn2  Location: Chr4:120161206-120167360 bp, + strand  Genetic Position: Chr4, 55.77 cM
Decreased body weight in Edn2tm1Ywa/Edn2tm1Ywa mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201436
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of exon 1 and all of exon 2. RT-PCR confirmed the absence of transcript expression in the stomach, small intestine and colon. (J:201436)
Generation of the Edn2tm1Ywa allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Edn2 Mutation:  11 strains or lines available
References
Original:  J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory