Lats2tm1.1Hlee
Targeted Allele Detail
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Symbol: |
Lats2tm1.1Hlee |
Name: |
large tumor suppressor 2; targeted mutation 1.1, Ho Lee |
MGI ID: |
MGI:5518609 |
Synonyms: |
Lats2fl, Lats2flox |
Gene: |
Lats2 Location: Chr14:57927119-57983669 bp, - strand Genetic Position: Chr14, 30.28 cM
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Alliance: |
Lats2tm1.1Hlee page
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Germline Transmission: |
Earliest citation of germline transmission:
J:198940
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 3. A second loxP site was inserted into intron 4. Flp-mediated recombination removed the neo cassette and left exon 4 floxed.
(J:198940)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lats2 Mutation: |
42 strains or lines available
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Original: |
J:198940 Kim M, et al., cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J. 2013 May 29;32(11):1543-55 |
All: |
6 reference(s) |
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