Pla2g2d^tm1.1Mhg
Targeted Allele Detail

Summary

• Symbol: Pla2g2d^tm1.1Mhg
• Name: phospholipase A2, group IID; targeted mutation 1.1, Michael H Gelb
• MGI ID: MGI:5517549
• Gene: Pla2g2d Location: Chr4:138503046-138509357 bp, + strand Genetic Position: Chr4, 70.57 cM
• Alliance: Pla2g2d^tm1.1Mhg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197334
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inswerted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 2, exon 3 and the neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the spleen. (J:201008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g2d Mutation: 8 strains or lines available

References

• Original: J:197334 Taketomi Y, et al., Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol. 2013 Jun;14(6):554-63
• All: 7 reference(s)