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Transgene Detail
Symbol: Tg(ACTA1-TRPC6*)1Jmol
Name: transgene insertion 1, Jeffery Molkentin
MGI ID: MGI:5516499
Synonyms: dnTRPC6 TG
Transgene: Tg(ACTA1-TRPC6*)1Jmol  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(ACTA1-TRPC6*)1Jmol expresses 1 gene
Mutation detailsA modified human ACTA1 skeletal alpha-actin promoter (-2000 to +239drives muscle-specific expression of a dominant negative form of human TRPC6 cDNA in which three highly conserved amino acids (L678-W680) within the putative pore region were replaced with alanine residues. Line 1 was generated. (J:154908)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:154908 Millay DP, et al., Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19023-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory