Tg(ACTA1-TRPC6*)1Jmol
Transgene Detail

Summary

• Symbol: Tg(ACTA1-TRPC6*)1Jmol
• Name: transgene insertion 1, Jeffery Molkentin
• MGI ID: MGI:5516499
• Synonyms: dnTRPC6 TG
• Transgene: Tg(ACTA1-TRPC6*)1Jmol Location: unknown
• Alliance: Tg(ACTA1-TRPC6*)1Jmol page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-TRPC6*)1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TRPC6 (7225)

  Trpc6

  (MGI:109523)

• Mutation details: A modified human ACTA1 skeletal alpha-actin promoter (-2000 to +239drives muscle-specific expression of a dominant negative form of human TRPC6 cDNA in which three highly conserved amino acids (L678-W680) within the putative pore region were replaced with alanine residues. Line 1 was generated. (J:154908)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:154908 Millay DP, et al., Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism. Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19023-8
• All: 1 reference(s)