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Pdcltm1.1Bmw
Targeted Allele Detail
Summary
Symbol: Pdcltm1.1Bmw
Name: phosducin-like; targeted mutation 1.1, Barry M Willardson
MGI ID: MGI:5516193
Synonyms: PhLP1F
Gene: Pdcl  Location: Chr2:37240086-37249344 bp, - strand  Genetic Position: Chr2, 24.19 cM
Alliance: Pdcltm1.1Bmw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197148
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted in intron 1 just upstream of exon 2 and its start codon. An FRT flanked neomycin selection cassette followed by a second loxP site was also inserted in intron 3. Properly targeted chimeric mice were then bred to mice expressing flp recombinase leading to excision of the selection cassette. (J:197148)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdcl Mutation:  22 strains or lines available
References
Original:  J:197148 Lai CW, et al., Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors. J Neurosci. 2013 May 1;33(18):7941-51
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory