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Kdm6atm1b(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Kdm6atm1b(EUCOMM)Wtsi
Name: lysine (K)-specific demethylase 6A; targeted mutation 1b, Wellcome Trust Sanger Institute
MGI ID: MGI:5516011
Synonyms: XUtxGT2Delta
Gene: Kdm6a  Location: ChrX:18162575-18279936 bp, + strand  Genetic Position: ChrX, 13.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:201868
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe L1L2_gt0 cassette was inserted at position 18198728 of Chromosome X upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 18199550. The critical exon is thus flanked by loxP sites. Subsequent cre expression resulted in a knockout mouse. Deletion of the third exon produces a frameshift and introduction of a translational stop codon when Utx is spliced from exon 2 to exon 4. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:201868)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm6a Mutation:  38 strains or lines available
References
Original:  J:201868 Shpargel KB, et al., UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet. 2012 Sep;8(9):e1002964
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory