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Tg(Shank3-EGFP)1Hzo
Transgene Detail
Nomenclature
Symbol: Tg(Shank3-EGFP)1Hzo
Name: transgene insertion 1, Huda Y Zoghbi
MGI ID: MGI:5515936
Synonyms: EGFP-Shank3, Shank3-EGFP
Transgene: Tg(Shank3-EGFP)1Hzo  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Mutation detailsBacterial artificial chromosome RP23-278D8 was modified to contain a Kozak sequence (ACCATGG) followed by enhanced green fluorescent protein (EGFP) sequence at the start codon. Line 1 was generated. Mice carrying this transgene overexpress all 3 of the major Shank3 isoforms. (J:201867)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:201867 Han K, et al., SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013 Nov 7;503(7474):72-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory