Setdb1^MommeD17
Chemically induced Allele Detail

Summary

• Symbol: Setdb1^MommeD17
• Name: SET domain, bifurcated 1; modifier of murine metastable epialleles, D17
• MGI ID: MGI:5515364
• Gene: Setdb1 Location: Chr3:95230836-95264513 bp, - strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Setdb1^MommeD17 page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: A T-to-C single point mutation in exon 21 is predicted to result in a V1248A amino acid substitution in the encoded protein. Reduced amounts of encoded protein were detected on Western blot of embryonic tissue, suggesting that this allele is hypomorphic. (J:201508)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Setdb1 Mutation: 58 strains or lines available

References

• Original: J:201508 Daxinger L, et al., An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol. 2013 Sep 11;14(9):R96
• All: 1 reference(s)