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Tyrp1b-Btlr
Chemically induced Allele Detail
Nomenclature
Symbol: Tyrp1b-Btlr
Name: tyrosinase-related protein 1; brown Bruce Beutler
MGI ID: MGI:5515343
Synonyms: chi
Gene: Tyrp1  Location: Chr4:80834123-80851719 bp, + strand  Genetic Position: Chr4, 37.89 cM
Brown coat color of the homozygous Tyrp1b-Btlr mouse

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced an A to G transition at base pair 80840778 (v38) on chromosome 4 in the GenBank genomic region NC_000070 encoding Tyrp1. The mutation corresponds to residue 1159 in the mRNA sequence (NM_031202.2) in exon 4 of 8 total exons. The mutation results in a conversion of tyrosine (Y) to cysteine (C) at residue 296. (J:201717)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyrp1 Mutation:  177 strains or lines available
References
Original:  J:201717 Purrington T, et al., Direct data submission for chi. MGI Direct Data Submission. 2013;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory