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Targeted Allele Detail
Symbol: Sgpl1tm1.1Npa
Name: sphingosine phosphate lyase 1; targeted mutation 1.1, Novartis Pharma AG
MGI ID: MGI:5514381
Gene: Sgpl1  Location: Chr10:61098642-61147684 bp, - strand  Genetic Position: Chr10, 32.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:199525
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to use for homologous recombination to flank exon 8 of Sgpl1 with loxP sites b. An frt-neo-frt cassette was also inserted. Chimeric mice were crossed to C57BL/6 mice and then crossed with flp deleter mice to remove the neo. (J:199525)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sgpl1 Mutation:  16 strains or lines available
Original:  J:199525 Billich A, et al., Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLoS One. 2013;8(3):e59630
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory