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Map3k7tm1Mis
Targeted Allele Detail
Summary
Symbol: Map3k7tm1Mis
Name: mitogen-activated protein kinase kinase kinase 7; targeted mutation 1, Yuji Mishina
MGI ID: MGI:5514175
Synonyms: Tak1FX
Gene: Map3k7  Location: Chr4:31964097-32023467 bp, + strand  Genetic Position: Chr4, 13.91 cM
Alliance: Map3k7tm1Mis page
Mandibular hypoplasia and cleft palate in Map3k7tm1Mis/Map3k7tm1MisH2az2Tg(Wnt1-cre)11Rth/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198588
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn HPRT cassette with a 3' lox66 site was inserted upstream of exon 2. A lox71 site was inserted downstream of exon 2. Cre-mediated recombination is required to invert exon 2 and inactivate the gene. (J:198588)
Generation of the Map3k7tm1Mis allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k7 Mutation:  51 strains or lines available
References
Original:  J:198588 Yumoto K, et al., TGF-beta-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells. J Biol Chem. 2013 May 10;288(19):13467-80
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory