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Targeted Allele Detail
Symbol: Rgs13tm1.1Jhk
Name: regulator of G-protein signaling 13; targeted mutation 1.1, John H Kehrl
MGI ID: MGI:5514157
Gene: Rgs13  Location: Chr1:144138654-144177372 bp, - strand  Genetic Position: Chr1, 62.56 cM
Large germinal centers in Rgs13tm1.1Jhk/Rgs13tm1.1Jhk mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:199530
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe coding region contained without exon 3 was replaced with EGFP and floxed neomycin resistance cassette. Cre-mediated recombination removed the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expression in splenic B cells or Peyer's Patch B. (J:199530)
Construction of the Rgs13tm1.1Jhk allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rgs13 Mutation:  10 strains or lines available
Original:  J:199530 Hwang IY, et al., Rgs13 constrains early B cell responses and limits germinal center sizes. PLoS One. 2013;8(3):e60139
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory