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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1.1Ksvo
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Karel Svoboda
MGI ID: MGI:5512720
Synonyms: Rosa26-LSL-H2B-mCherry
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, Humanized sequence, No functional change, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to contain a CAG promoter, followed by a loxP-STOP-LoxP (LSL) sequence and an H2B-mCherry fusion protein (coding sequence for the human HIST1H2BB gene [histone 1 H2bb] followed C-terminally by Enhanced Red Fluorescent Protein gene) An AttB-PGKNeo-AttP cassette was placed downstream of the H2B-mCherry fusion protein. This entire construct was inserted into the Gt(ROSA)26Sor locus. PhiC31-mediated recombination removed the neomycin resistance cassette. (J:221246)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  745 strains or lines available
Original:  J:221246 Peron SP, et al., A Cellular Resolution Map of Barrel Cortex Activity during Tactile Behavior. Neuron. 2015 May 6;86(3):783-99
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory