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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm6(Fzd6)Nat
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Jeremy Nathans
MGI ID: MGI:5510965
Synonyms: R26-LSL-3HAFz6, ROSA26-3xHA-Fz6
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:217610
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change)
Mutation:    Insertion
Gt(ROSA)26Sortm6(Fzd6)Nat expresses 1 gene
Mutation detailsThe following elements were inserted, in the following order, into the locus by homologous recombination: loxP-three stop transcription signals-loxP, a Fzd6 coding region with a triple hemagglutinin (HA) tag inserted immediately C-terminal to the signal peptide. (J:217610)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  741 strains or lines available
Original:  J:217610 Hua ZL, et al., Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance. Development. 2014 Oct;141(20):3944-54
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory