Rc3h2^tm1.1Cgv
Targeted Allele Detail

Summary

• Symbol: Rc3h2^tm1.1Cgv
• Name: ring finger and CCCH-type zinc finger domains 2; targeted mutation 1.1, Carola Vinuesa
• MGI ID: MGI:5508926
• Gene: Rc3h2 Location: Chr2:37260081-37312915 bp, - strand Genetic Position: Chr2, 24.19 cM
• Alliance: Rc3h2^tm1.1Cgv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196137
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exon 2 and an FRT flanked neo cassette was inserted in intron 2. Properly targeted micd were then crossed to mice expressing flp recombinase to remove the selection cassette. (J:196137)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rc3h2 Mutation: 70 strains or lines available

References

• Original: J:196137 Pratama A, et al., Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation. Immunity. 2013 Apr 18;38(4):669-80
• All: 2 reference(s)