Prmt6^tm1.1Rchd
Targeted Allele Detail

Summary

• Symbol: Prmt6^tm1.1Rchd
• Name: protein arginine N-methyltransferase 6; targeted mutation 1.1, Stephane Richard
• MGI ID: MGI:5508652
• Synonyms: PRMT6^FL
• Gene: Prmt6 Location: Chr3:110153425-110158314 bp, - strand Genetic Position: Chr3, 48.52 cM
• Alliance: Prmt6^tm1.1Rchd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199753
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. A loxP- and FRT-flanked neomycin resistance cassette was inserted downstream of exon 1. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed. (J:199753)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prmt6 Mutation: 22 strains or lines available

References

• Original: J:199753 Neault M, et al., Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res. 2012 Oct;40(19):9513-21
• All: 1 reference(s)