Tg(Mef2c-lacZ)#bBlk
Transgene Detail

Summary

• Symbol: Tg(Mef2c-lacZ)#bBlk
• Name: transgene insertion #b, Brian L Black
• MGI ID: MGI:5508561
• Synonyms: Mef2c[3-3.3]-F1-TKlacZ
• Transgene: Tg(Mef2c-lacZ)#bBlk Location: unknown
• Alliance: Tg(Mef2c-lacZ)#bBlk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The 300-bp conserved region of the Mef2c-F1 enhancer fragment was used to direct expression of Hspa1b-lacZ. This 300-bp region (3-3.3 kb) contains conserved MEF2- and SOX-binding sites, is both sufficient and crucial for Mef2c-F1 neural crest enhancer activity in vivo, and directs beta-gal expression in the same pattern as the full length Mef2c-F1 fragment at E11.5. (J:173609)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:173609 Agarwal P, et al., The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development. 2011 Jun;138(12):2555-65
• All: 2 reference(s)