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Kdm6atm1b(EUCOMM)Jae
Targeted Allele Detail
Nomenclature
Symbol: Kdm6atm1b(EUCOMM)Jae
Name: lysine (K)-specific demethylase 6A; targeted mutation 1b, Rudolf Jaenisch
MGI ID: MGI:5507843
Synonyms: Utxko
Gene: Kdm6a  Location: ChrX:18162575-18279936 bp, + strand  Genetic Position: ChrX, 13.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188485
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was obtained from the European knockout consortium (EUCOMM). The targeting construct contains a splice acceptor, beta-geo cassette flanked by two Flp sites preceding the third exon. In addition, the targeting construct introduced two loxP sites on either side of exon 3. Transient cre expression resulted in the excision of exon 3 while leaving the FRT flanked beta-geo intact. (J:188485)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm6a Mutation:  38 strains or lines available
References
Original:  J:188485 Welstead GG, et al., X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13004-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory