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Targeted Allele Detail
Symbol: Kdm6atm1a(EUCOMM)Jae
Name: lysine (K)-specific demethylase 6A; targeted mutation 1a, Rudolf Jaenisch
MGI ID: MGI:5507841
Synonyms: Utxhyp
Gene: Kdm6a  Location: ChrX:18162575-18279936 bp, + strand  Genetic Position: ChrX, 13.45 cM
Germline Transmission:  Earliest citation of germline transmission: J:188485
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector was obtained from the European knockout consortium (EUCOMM). The targeting construct contains a splice acceptor, beta-geo cassette flanked by two Flp sites preceding the third exon. In addition, the targeting construct introduced two loxP sites on either side of exon 3, allowing for conditional ablation of the exon upon the addition of cre recombinase. The flp sites flanking the splice acceptor beta-geo cassette allow for its removal after the addition of the flipase enzyme resulting in the generation of a conditional allele. (J:188485)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm6a Mutation:  38 strains or lines available
Original:  J:188485 Welstead GG, et al., X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13004-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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