Kdm6a^{tm1a(EUCOMM)Jae}
Targeted Allele Detail

Summary

• Symbol: Kdm6a^{tm1a(EUCOMM)Jae}
• Name: lysine (K)-specific demethylase 6A; targeted mutation 1a, Rudolf Jaenisch
• MGI ID: MGI:5507841
• Synonyms: Utx^hyp
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^{tm1a(EUCOMM)Jae} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188485
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was obtained from the European knockout consortium (EUCOMM). The targeting construct contains a splice acceptor, beta-geo cassette flanked by two Flp sites preceding the third exon. In addition, the targeting construct introduced two loxP sites on either side of exon 3, allowing for conditional ablation of the exon upon the addition of cre recombinase. The flp sites flanking the splice acceptor beta-geo cassette allow for its removal after the addition of the flipase enzyme resulting in the generation of a conditional allele. (J:188485)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 38 strains or lines available

References

• Original: J:188485 Welstead GG, et al., X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13004-9
• All: 1 reference(s)