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Kdm6atm1c(EUCOMM)Jae
Targeted Allele Detail
Nomenclature
Symbol: Kdm6atm1c(EUCOMM)Jae
Name: lysine (K)-specific demethylase 6A; targeted mutation 1c, Rudolf Jaenisch
MGI ID: MGI:5507836
Synonyms: Utxflx
Gene: Kdm6a  Location: ChrX:18028814-18146175 bp, + strand  Genetic Position: ChrX, 13.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188485
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA targeting vector, obtained from EUCOMM, containing a FRT site flanked beta-geo cassette and a loxP site was inserted upstream of exon 3. A second loxP site was inserted downstream of exon 3. ES cells were transiently transfected with a FLP recombinase vector to remove the selection cassette. (J:188485)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdm6a Mutation:  39 strains or lines available
References
Original:  J:188485 Welstead GG, et al., X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13004-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory