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Cd68tm1.1Shnd
Targeted Allele Detail
Nomenclature
Symbol: Cd68tm1.1Shnd
Name: CD68 antigen; targeted mutation 1.1, Christian Schindler
MGI ID: MGI:5506645
Gene: Cd68  Location: Chr11:69664213-69666153 bp, - strand  Genetic Position: Chr11, 42.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175275
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to place an rtTA (reverse tetracycline regulated transactivator) and a loxP-flanked neomycin resistance (neo) cassette downstream of the transcriptional start site. Correctly targeted mice were bred to cre expressing mice to delete the neo cassette and the resulting offspring were bred together to remove the cre-expressing transgene. (J:175275)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd68 Mutation:  26 strains or lines available
References
Original:  J:175275 Song L, et al., Deletion of the murine scavenger receptor CD68. J Lipid Res. 2011 Aug;52(8):1542-50
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory