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Targeted Allele Detail
Symbol: Scn3atm1.2Jwo
Name: sodium channel, voltage-gated, type III, alpha; targeted mutation 1.2, John N Wood
MGI ID: MGI:5505523
Synonyms: Nav1.3 KO
Gene: Scn3a  Location: Chr2:65457118-65567591 bp, - strand  Genetic Position: Chr2, 38.55 cM
Germline Transmission:  Earliest citation of germline transmission: J:199857
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe targeting construct introduced loxP sites flanking exons 4 and 5 and a FRT-flanked neomycin resistance cassette following the second loxP site. The selection cassette was deleted by crossing mice carrying the original targeted allele with mice expressing flpe recombinase in the germline. Expression of Cre recombinase then deleted 221 base pairs of the gene encompassing exon 4, intron 4 and exon 5. (J:199857)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn3a Mutation:  9 strains or lines available
Original:  J:199857 Nassar MA, et al., Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain. 2006;2:33
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory