Scn3a^tm1.2Jwo
Targeted Allele Detail

Summary

• Symbol: Scn3a^tm1.2Jwo
• Name: sodium channel, voltage-gated, type III, alpha; targeted mutation 1.2, John N Wood
• MGI ID: MGI:5505523
• Synonyms: Nav1.3 KO
• Gene: Scn3a Location: Chr2:65288607-65397971 bp, - strand Genetic Position: Chr2, 38.55 cM
• Alliance: Scn3a^tm1.2Jwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199857
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct introduced loxP sites flanking exons 4 and 5 and a FRT-flanked neomycin resistance cassette following the second loxP site. The selection cassette was deleted by crossing mice carrying the original targeted allele with mice expressing flpe recombinase in the germline. Expression of Cre recombinase then deleted 221 base pairs of the gene encompassing exon 4, intron 4 and exon 5. (J:199857)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn3a Mutation: 110 strains or lines available

References

• Original: J:199857 Nassar MA, et al., Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain. 2006;2:33
• All: 5 reference(s)