Washc1^tm1.1Ddb
Targeted Allele Detail

Summary

• Symbol: Washc1^tm1.1Ddb
• Name: WASH complex subunit 1; targeted mutation 1.1, Daniel D Billadeau
• MGI ID: MGI:5504467
• Synonyms: WASH^flox
• Gene: Washc1 Location: Chr17:66418540-66427498 bp, + strand Genetic Position: Chr17, 35.26 cM, cytoband F3-F4
• Alliance: Washc1^tm1.1Ddb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199703
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:199703)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Washc1 Mutation: 11 strains or lines available

References

• Original: J:199703 Gomez TS, et al., Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell. 2012 Aug;23(16):3215-28
• All: 9 reference(s)