Fbxl21^tm1Kei
Targeted Allele Detail

Summary

• Symbol: Fbxl21^tm1Kei
• Name: F-box and leucine-rich repeat protein 21; targeted mutation 1, Keiichi I Nakayama
• MGI ID: MGI:5503967
• Gene: Fbxl21 Location: Chr13:56670285-56685711 bp, + strand Genetic Position: Chr13, 30.07 cM
• Alliance: Fbxl21^tm1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196293
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced the coding sequence of exon 4 and 5 with an IRES-lacZ and floxed neomycin resistance cassette. Real-time PCR confirmed the absence of transcript expression in the liver. (J:196293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxl21 Mutation: 25 strains or lines available

References

• Original: J:196293 Hirano A, et al., FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell. 2013 Feb 28;152(5):1106-18
• All: 1 reference(s)