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Targeted Allele Detail
Symbol: Tab3tm1Aki
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 3; targeted mutation 1, Shizuo Akira
MGI ID: MGI:5502690
Gene: Tab3  Location: ChrX:85574022-85634469 bp, + strand  Genetic Position: ChrX, 39.32 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:195289
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAlmost all of exons 2 and 3 were replaced by a neomycin resistance cassette. Absence of mRNA in properly targeted mice was confirmed by PCR. (J:195289)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tab3 Mutation:  12 strains or lines available
Original:  J:195289 Ori D, et al., Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs. J Immunol. 2013 Apr 15;190(8):4037-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory