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Targeted Allele Detail
Symbol: Eif2ak3tm1.2Drc
Name: eukaryotic translation initiation factor 2 alpha kinase 3; targeted mutation 1.2, Douglas R Cavener
MGI ID: MGI:5502572
Gene: Eif2ak3  Location: Chr6:70844515-70905245 bp, + strand  Genetic Position: Chr6, 32.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:76661
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsTwo loxP sites were introduced to intronic regions flanking the three exons encoding part of the lumenal domain, the transmembrane domain, and part of the catalytic domain. A third loxP site was introduced with a PGK-neo cassette directly downstream of the second loxP site in the same intron. Cre-mediated recombination removed the neo cassette and left the three exons floxed. (J:76661)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Eif2ak3 Mutation:  8 strains or lines available
Original:  J:76661 Zhang P, et al., The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol. 2002 Jun;22(11):3864-74
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory