Prickle1^tm1.1Asw
Targeted Allele Detail

Summary

• Symbol: Prickle1^tm1.1Asw
• Name: prickle planar cell polarity protein 1; targeted mutation 1.1, Anand Swaroop
• MGI ID: MGI:5502459
• Synonyms: Pk1-eYFP
• Gene: Prickle1 Location: Chr15:93396995-93493772 bp, - strand Genetic Position: Chr15, 47.69 cM
• Alliance: Prickle1^tm1.1Asw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198157
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An FRT site, splice acceptor, EYFP, loxP site, neomycin resistance (neo) cassette, FRT site and loxP site were inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left the EYFP intact and exon 2 floxed. Immunohistochemistry confirmed the absence of protein expression in most interneurons in the brain. (J:198157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prickle1 Mutation: 34 strains or lines available

References

• Original: J:198157 Liu C, et al., Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis. Hum Mol Genet. 2013 Jun 1;22(11):2234-46
• All: 1 reference(s)