Cdkn2a^tm1.1Gsu
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm1.1Gsu
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1.1, Gloria H Su
• MGI ID: MGI:5502377
• Synonyms: p16^f
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm1.1Gsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198619
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance (neo) cassette with a loxP site was inserted upstream of exon E1A. An additional loxP site was inserted downstream of exon E1A. Flp-mediated recombination removed the neo cassette and left exon E1A floxed. (J:198619)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 62 strains or lines available

References

• Original: J:198619 Qiu W, et al., Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo. Oncotarget. 2011 Nov;2(11):862-73
• All: 5 reference(s)