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Targeted Allele Detail
Symbol: Nabp2tm1.1Kkha
Name: nucleic acid binding protein 2; targeted mutation 1.1, Kum Kum Khanna
MGI ID: MGI:5502334
Synonyms: Ssb1fl
Gene: Nabp2  Location: Chr10:128401395-128411492 bp, - strand  Genetic Position: Chr10, 76.55 cM, cytoband D3
Testicular degeneration in Nabp2tm1.1Kkha/Nabp2tm1.1Kkha Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:195140
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 3 through 6 were floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette and left exons 3 through 6 floxed. (J:195140)
Generation of the Nabp2tm1.1Kkha and Nabp2tm1.2Kkha alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nabp2 Mutation:  17 strains or lines available
Original:  J:195140 Shi W, et al., Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013 Feb;9(2):e1003298
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory