Bcl6^tm1.1Meln
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm1.1Meln
• Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Ari Melnick
• MGI ID: MGI:5502178
• Synonyms: Bcl6^BTBMUT
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm1.1Meln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194821
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A mutation resulting in an N21K change in exon 3 and a second mutation resulting in an H116A change in exon 4 were introduced. In addition, a floxed neomycin resistance cassette was inserted in an intron ~3800 bp upstream of codon 116. The resistance cassette was subsequently removed from properly targeted mice by cre excision. (J:194821)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 55 strains or lines available

References

• Original: J:194821 Huang C, et al., Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms. Nat Immunol. 2013 Apr;14(4):380-8
• All: 3 reference(s)