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Targeted Allele Detail
Symbol: Myod1tm2Glh
Name: myogenic differentiation 1; targeted mutation 2, David J Goldhamer
MGI ID: MGI:5500171
Synonyms: DRRneo
Gene: Myod1  Location: Chr7:46376474-46379099 bp, + strand  Genetic Position: Chr7, 30.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:76260
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.9-kb genomic fragment containing the 714-bp downstream regulatory region was replaced with a PGKneo-positive selection cassette flanked by loxP sites. Whole-mount in situ hybridization and northern blot analysis confirmed reduced transcript expression in all myogenic population. (J:76260)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myod1 Mutation:  6 strains or lines available
Original:  J:76260 Chen JC, et al., Essential and redundant functions of the MyoD distal regulatory region revealed by targeted mutagenesis. Dev Biol. 2002 May 1;245(1):213-23
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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