Col1a1^{tm7(CAG-Mycl,-luc2)Nki}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm7(CAG-Mycl,-luc2)Nki}
• Name: collagen, type I, alpha 1; targeted mutation 7, The Netherlands Cancer Institute
• MGI ID: MGI:5499626
• Synonyms: Col1a1^{tm7(Mycl-luc2)Nki}, invCAG-Mycl1-Luc2
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm7(CAG-Mycl,-luc2)Nki} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210103
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: RMCE introduced into the 3' UTR an FRT-flanked cassette containing an inverted lox71/lox66-flanked CAG promoter, full-length Mycl sequence, IRES sequence and firefly luciferase reporter gene (fLuc2). (J:210103)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 166 strains or lines available

Notes

Parental ES cells were derived from FVB.129P2-Trp53^tm1Brn Rb1^tm2Brn mice.

References

• Original: J:210103 Huijbers IJ, et al., Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med. 2014 Feb;6(2):212-25
• All: 4 reference(s)